内容简介:BackgroundThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mecha
Background
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients. Currently, there is no evidence to support the use of hydroxychloroquine in SARS-CoV-2 infection.
Methods
The pharmacological activity of chloroquine and hydroxychloroquine was tested using SARS-CoV-2 infected Vero cells. Physiologically-based pharmacokinetic models (PBPK) were implemented for both drugs separately by integrating their in vitro data. Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen whilst considering the drug’s safety profile.
Results
Hydroxychloroquine (EC 50 =0.72 μM) was found to be more potent than chloroquine (EC 50 =5.47 μM) in vitro . Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance.
Conclusions
Hydroxychloroquine was found to be more potent than chloroquine to inhibit SARS-CoV-2 in vitro.
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快速傅里叶变换
K. R. Rao、D. N. Kim、J. J. Hwang / 万帅、杨付正 / 机械工业出版社 / 2013-3 / 98.00元
《国际信息工程先进技术译丛·快速傅里叶变换:算法与应用》深入浅出地阐述了快速傅里叶变换(FFT)的原理,系统地总结了各类FFT算法,并广泛精辟地介绍了FFT在视频和音频信号处理中的各种应用。《国际信息工程先进技术译丛·快速傅里叶变换:算法与应用》在阐述了离散傅里叶变换(DFT)的原理和性质之后,详细讨论了时域抽取(DIT)和频域抽取(DIF)的各类快速算法。论述了近似计算DFT的整数FFT、二维及......一起来看看 《快速傅里叶变换》 这本书的介绍吧!