Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Reversing
艾拉姆（Eilam,E.） / 韩琪、杨艳、王玉英、李娜 / 电子工业出版社 / 2007-9 / 79.00元
本书描述的是在逆向与反逆向之间展开的一场旷日持久的拉锯战。作者Eldad Eilam以一个解说人的身份为我们详尽地评述了双方使用的每一招每一式的优点与不足。 书中包含的主要内容有：操作系统的逆向工程；.NET平台上的逆向工程；逆向未公开的文件格式和网络协议；逆向工程的合法性问题；拷贝保护和数字版权管理技术的逆向工程；防止别人对你的代码实施逆向工程的各种技术；恶意程序的逆向工程；反编译器的基本......一起来看看 《Reversing》 这本书的介绍吧!
