Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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游戏化思维
[美] 凯文·韦巴赫（Kevin Werbach）、[美] 丹·亨特（Dan Hunter） / 周逵、王晓丹 / 浙江人民出版社 / 2014-4 / 36.90
[内容简介] ●本书由开设了全世界第一个游戏化课程的沃顿商学院副教授凯文·韦巴赫和丹·亨特所著，第一次全面系统地介绍游戏化的理论，阐述了如何将游戏的理念应用到商业实践中。 ●作者指出，在商业竞争日益激烈的今天，传统的激励方式渐渐失效，未来的管理将更多地建立在员工和消费者的内在动机和自我激励上。这些制作精良、设计巧妙的游戏建立在多年来对人类动机和人类心理的研究基础之上，可以最大限度地激发......一起来看看 《游戏化思维》 这本书的介绍吧!
