Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
以上所述就是小编给大家介绍的《2019-nCoV may contain a gain-of-function for efficient spreading》，希望对大家有所帮助，如果大家有任何疑问请给我留言，小编会及时回复大家的。在此也非常感谢大家对 码农网 的支持！
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卓有成效的程序员
Neal Ford / 熊节 / 机械工业出版社 / 2009-3 / 45.00元
《卓有成效的程序员》就是讲述如何在开发软件的过程中变得更加高效。同时，《卓有成效的程序员》的讲述将会跨语言和操作系统：很多技巧的讲述都会伴随多种程序语言的例子，并且会跨越三种主要的操作系统，Windows（多个版本），Mac OS X以及 *-nix (Unix或者Linux)。 《卓有成效的程序员》讨论的是程序员个体的生产力，而不是团队的生产力问题，所以它不会涉及方法论（好吧，可能总会在......一起来看看 《卓有成效的程序员》 这本书的介绍吧!
