Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Web Designer Idea
梁景红 / 电子工业出版社 / 2006年 / ¥55.00
这是一本以“目的、信息、设计、创意”作为根脉的关于网页视觉的书籍，畅谈的话题从策划到编辑再到设计，从而讨论“我们要建立怎样的站点，并以何种形式完成它”的问题。 全书共分四个部分，分别是网站建设目的，网站信息内容，页面形式设计，网页创作构思。 四部分有机地结合，形成一个统一的整体。“目的”部分以建设网站的目的为主，带领设计师从建站目的的角度，探讨如何抓住首要问题；如何建立网站雏形；如何打开狭隘的、局......一起来看看 《Web Designer Idea》 这本书的介绍吧!
